Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task
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چکیده
منابع مشابه
Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction.
Rats were subjected to one or two cycles of context fear conditioning and extinction to study the roles of the prelimbic cortex (PL) and infralimbic cortex (IL) in learning and relearning to inhibit fear responses. Inactivation of the PL depressed fear responses across the first or second extinction but did not impair learning or relearning fear inhibition (experiment 1). Inactivation of the IL...
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Deficits in decision-making is a hallmark of several neuropsychiatric pathologies but is also observed in some healthy individuals that could be at risk to develop these pathologies. Poor decision-making can be revealed experimentally in humans using the Iowa gambling task, through the inability to select options that ensure long term gains over larger immediate gratification. We devised an ana...
متن کاملPrelimbic/infralimbic inactivation impairs memory for multiple task switches, but not flexible selection of familiar tasks.
Behavioral flexibility, in the form of strategy switching or set shifting, helps animals cope with changing contingencies in familiar environments. The prelimbic (PL) and infralimbic (IL) regions of the rat prefrontal cortex (PFC) contribute to this ability so that rats trained to use one strategy have difficulty learning a new one if the PL/IL is inactivated. Thus, the PL/IL mediates learning ...
متن کاملElucidating Poor Decision-Making in a Rat Gambling Task
Although poor decision-making is a hallmark of psychiatric conditions such as attention deficit/hyperactivity disorder, pathological gambling or substance abuse, a fraction of healthy individuals exhibit similar poor decision-making performances in everyday life and specific laboratory tasks such as the Iowa Gambling Task. These particular individuals may provide information on risk factors or ...
متن کاملCorrection: Elucidating Poor Decision-Making in a Rat Gambling Task
There are several errors in the references within the Materials and Methods, Results, and Discussion sections of the manuscript. The corrected sentences that include updated references are below. Materials and Methods: In the first paragraph after Equation 1, the sentence should read: ‘‘The reward received after taking action a in state s is described by a state-action pair value Q(s,a), which ...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2015
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-015-4075-y